Ligand bias in receptor tyrosine kinase signaling
نویسندگان
چکیده
منابع مشابه
Receptor tyrosine kinase signaling in vascular development.
The formation and maintenance of the vascular circulatory system is of utmost importance during embryonic and postnatal life. The first organ system to develop is the cardiovascular network of endothelial cells that carry blood cells and metabolites throughout the embryo (1 , 2). Indeed, a functional vascular system is crucial for the rapid growth of postimplantation embryos. The vascular syste...
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Flotillins are highly conserved proteins that localize into specific cholesterol rich microdomains in cellular membranes. They have been shown to be associated with, for example, various signaling pathways, cell adhesion, membrane trafficking and axonal growth. Recent findings have revealed that flotillins are frequently overexpressed in various types of human cancers. We here review the sugges...
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Acute myeloid leukemia (AML) is a quickly progressing, heterogeneous clonal disorder of hematopoietic progenitor cells. Significant progress in understanding the pathogenesis of AML has been achieved in the past few years. Two major types of genetic events are thought to give rise to leukemic transformation: alterations in the activity of transcription factors controlling hematopoietic differen...
متن کاملMer receptor tyrosine kinase signaling participates in platelet function.
OBJECTIVE Recently, mice made deficient in growth arrest-specific gene 6 product (Gas6) or in which Gas6 gene expression was inhibited were shown to have platelet dysfunction and to be less susceptible to thrombosis. The aim of this study was to define and characterize the relevant Gas6 receptor or receptors involved in platelet function. METHODS AND RESULTS Using RT-PCR and Western blot anal...
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the pathways may be functionally redundant (Figure 1A). Many signal transduction mechanisms transmit informaIf this view is correct, RTK pathways may function merely tion from the extracellular space or an intracellular comto activate transcription factors generically, whose acpartment to the nucleus where they influence gene extivities would determine the consequences of signaling pression. Th...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2020
ISSN: 0021-9258
DOI: 10.1074/jbc.rev120.015190